Concomitant tricuspid regurgitation (TR), however, is less prevalent than MR in TAVI population, and majority of significant TR are secondary to pulmonary hypertension and right ventricle remodeling. Although no significant impact of MR on post-TAVI survival was reported in smaller cohorts, a meta-analysis demonstrated that significant MR was associated with increased 30-day (pooled odds ratio OR: 1.49, 95% confidence interval CI: 1.16–1.92) and 1-year mortality (pooled hazard ratio HR: 1.32, 95%CI: 1.12–1.55). The reported prevalence of significant (≥moderate) MR varies between 11.5% and 36.8% in cohorts of TAVI patients. Degenerative annular or valvular calcification was the leading cause of organic MR (92%), while 85% of functional MR was secondary to severe aortic stenosis in this group of patients. Of all the TAVI recipients with concomitant MR, functional MR consisted of 36% to 92% of the group. In a national registry-based cohort, mild, moderate, and severe mitral regurgitation (MR) at baseline were noted in 47.9%, 31.3% and 5.4% of patients who underwent the procedure, respectively. Mitral regurgitation (MR) is the most common valvular lesion in patients who underwent TAVI. Conclusions: Baseline MR and TR were associated with increased all-cause and cardiovascular mortality post-TAVI, however, neither of them was independent predictor for all-cause or cardiovascular mortality. Baseline MR was independently associated with rehospitalization for HF in TAVI patients. Neither baseline MR nor TR was an independent risk predictor for all-cause mortality or cardiovascular mortality in TAVI patients.
Patients with baseline MR have higher yearly incidence of all-cause mortality (HR: 1.192, 95% confidence interval CI: 1.125–1.263), cardiovascular mortality (HR: 1.313, 95%CI: 1.210–1.425), and rehospitalization for heart failure (HF) (HR: 1.411, 95%CI: 1.340–1.486) compared to those without, except for stroke rate (HR: 0.988, 95%CI: 0.868–1.124). Results: Baseline MR was identified in 8240 TAVI patients. All-cause and cardiovascular mortality, stroke, and rehospitalization with heart failure (HF) were compared in TAVI patients with and without baseline MR and tricuspid regurgitation (TR), respectively the associations of MR and TR with the outcomes were assessed by Cox regression. Methods: Adult patients who underwent TAVI were identified in the French National Hospital Discharge Database. This study aims to assess the long-term prognostic impact of baseline MR in TAVI patients. Mitral regurgitation (MR) is the most common valvular lesion in transcatheter aortic valve implantation (TAVI) recipients.